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Baseline Characteristics Associated with Survival in Patients with Hepatocellular Carcinoma
1Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Ege, Izmir, Turkey
2Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Koç, Istanbul, Turkey
3Ege University Medical Faculty, Department of Internal Medicine, Division of Gastroenterology, Izmir, Turkey
Hepatology Forum - DOI: 10.14744/hf.2021.2021.0031
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Background and Aim: HCC (hepatocellular carcinoma) is one of the most commonly seen and lethal cancers worldwide. We aimed to investigate the relationship between basal parameters, and survival characteristics in patients with HCC.
Material and Methods: In a tertiary center 1447 patients were screened between 2000 and 2017, retrospectively. The demographics, basal clinical, laboratory, and radiological characteristics, treatments, and survival time were recorded and prognostic scoring systems calculated.
Results: Seven hundred eighty eight patients (M/F: 623/ 165, mean age: 60. 5±10. 9) with HCC were included to the study. The median survival time was 26.3 months (95% CI, 22.3-30.4). The 5-year survival rate was 28.1%. The number and diameter of tumors, platelet count, platelet-to-lymphocyte ratio, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transferase, portal and hepatic vein involvement, AFP being <9.6 ng/ml were found independently related with survival.
Conclusions: The positive predictive value of the prognostic index derived from independent survival-related parameters in predicting 5- and 10-years survival or overall survival was approximately 86%. We should consider integrating this prognostic index into the criteria we use for the treatment decision of patients with HCC.