2Department of Internal Medicine, Helios Hospital Schleswig, Academical Educational Hospital of Luebeck and Kiel Universities, Schleswig, Germany
Background and Aims: The long-term sustainability of weight loss remains questionable. We investigated the effects of weight loss and the long-term sustainability of lifestyle modifications among obese patients with metabolic-associated fatty liver disease (MAFLD). Material and Methods: All patients were individually prescribed with a hypocaloric diet involving an ~500-kcal deficit, and they were followed up for 12 weeks in four face-to-face interviews. At the end of follow-up evaluations, at the 36th month of intervention, the patients were contacted, and their current weight was recorded. Results: The mean weight at baseline was 87 ± 13 kg, which decreased to 79 ± 11 kg after 12 weeks of intervention (P < 0.001). The mean weight at 36th month did not significantly differ from that at baseline (P = 0.563). The mean CAP decreased from 320 ± 13 dB/m to 273 ± 37 dB/m (P < 0.001), while the median liver stiffness measurement (LSM) reduced from 8.7 (3.6–45.7) kPa to 5.7 (2.2–29.9) kPa (P < 0.001). Conclusions: A strict follow-up through nutritional consultation can help achieve weight loss in obese patients with MAFLD. However, for long-term results, a collaboration of nutritionists and gastroenterologists is essential for preventing weight regain.