2Department of Gastroenterology, Istinye University, Istanbul,Turkey
Background and Aim: We aimed to investigate etiology, prognostic factors, treatment methods and the effects of these treatments on survival in HCC.
Material and Methods: This is a retrospective study including 158 patients diagnosed with HCC in our hospital between the years 2000 and 2010.
Results: Etiological factors were HBV in 53.2% of cases, HCV in 21.5%, alcohol in 6.3%, HBV+alcohol in 5.7%, HCV+Alcohol in 1.9%, HBV+HCV in 1.9%, and the etiology was unknown in 9.5%. Of the 158 patients, 120 were treated, of which 81 had follow-up data. The mean follow-up period was 17.9 months (0.6-124 months). According to multivariate analysis, lesion size greater than 5 cm, Child class C, higher creatinine levels, and distant metastasis were prognostic factors for survival.
Conclusion: In our study, hepatitis B virus was the most frequent cause of HCC, while hepatitis C virus was the second. The most effective treatment methods on survival in HCC were liver transplantation and hepatic resection in eligible patients. Lesion size greater than 5 cm, Child class C, higher creatinine levels, and distant metastasis were determined as independent prognostic factors for survival.