We present a case of POEMS syndrome from Turkiye, a rare, multisystem-ic condition resulting from plasma cell dyscrasia. POEMS is an acronym representing its cardinal features: Peripheral neuropathy; Organomegaly; Endocrinopathy; Monoclonal plasma-cell proliferative disorder; and Skin changes. The syndrome has an estimated prevalence of 0.3 per 100,000 individuals and typically manifests in the fifth or sixth decade of life. Pro-gressive peripheral neuropathy is the syndrome’s most prominent symptom. To ensure an accurate diagnosis, a thorough medical history, physical ex-amination, and comprehensive diagnostic evaluations are essential. These evaluations should include serum immunoelectrophoresis, serum cytokines, and growth factors, a skeletal survey, and a bone marrow biopsy. Early rec-ognition and treatment of POEMS syndrome are crucial to prevent debili-tating progression and to optimize clinical outcomes.