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From hepatomegaly to POEMS syndrome: A case report
1Division of Gastroenterology, Department of Internal Medicine, Erciyes University School of Medicine, Kayseri, Turkiye of Gastroenterology, Faculty of Medicine, Internal Medicine, Erciyes University, Kayseri
Hepatology Forum 2024; 5(1): 44-46 DOI: 10.14744/hf.2022.2022.0035 PMCID: PMC10809343
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We present a case of POEMS syndrome from Turkiye, a rare, multisystem-ic condition resulting from plasma cell dyscrasia. POEMS is an acronym representing its cardinal features: Peripheral neuropathy; Organomegaly; Endocrinopathy; Monoclonal plasma-cell proliferative disorder; and Skin changes. The syndrome has an estimated prevalence of 0.3 per 100,000 individuals and typically manifests in the fifth or sixth decade of life. Pro-gressive peripheral neuropathy is the syndrome’s most prominent symptom. To ensure an accurate diagnosis, a thorough medical history, physical ex-amination, and comprehensive diagnostic evaluations are essential. These evaluations should include serum immunoelectrophoresis, serum cytokines, and growth factors, a skeletal survey, and a bone marrow biopsy. Early rec-ognition and treatment of POEMS syndrome are crucial to prevent debili-tating progression and to optimize clinical outcomes.