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Effect of probiotics supplementation on liver stiffness and steatosis in patients with NAFLD
1Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh
2Pi Research Consultancy Center, Shahbag, Dhaka, Bangladesh
Hepatology Forum 2024; 5(1): 18-24 DOI: 10.14744/hf.2022.2022.0003 PMCID: PMC10809339
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Background and Aim: To compare the effects of probiotics on liver stiffness and steatosis in obese and non-obese patients with nonalco-holic fatty liver disease (NAFLD),the pragmatic clinical trial included 50 obese body mass index (BMI) ≥25 kg/m2 and 50 non-obese NAFLD BMI <25 kg/m2 age and sex-matched patients.
Material and Methods: Fibroscan with controlled attenuated param-eter (CAP) was done at day 0 and at the end of 6 months. Probiotics supplementation was provided for both groups for 6 months along with lifestyle modifications.
Results: At inclusion, both groups had comparable characteristics except BMI, metabolic syndrome and waist circumference (WC). Beneficial changes occurred in BMI (p=0.024), WC (p=0.045), ALT (p=0.024), total cholesterol (p=0.016), LDL (p=0.025) and triglycer-ide (p=0.021) of obese group, systolic blood pressure (p=0.003) and LDL level (p=0.018) in non-obese group. No significant change was observed in liver enzymes and glycemic profiles. Significant improve-ment in CAP was observed in both groups. But after adjusting for changes in BMI and WC, the change in CAP among non-obese par-ticipants were significantly higher compared to obese, mean change of 19.33±48.87 and 16.02±51.58 dB/m in non-obese and obese patients, respectively; p=0.044).
Conclusion: Probiotics improve CAP/ steatosis in both obese and non-obese NAFLD patients and improvement was higher in non-obese, irre-spective of BMI change.