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The pleiotropic approach to coronavirus disease-19 pathogenesis: The impact of liver diseases associated host genetic variants
1Marmara University School of Medicine, 3rd year Pre-Clinical Student, Istanbul, Turkiye;
2Department of Medical Biology, Marmara University School of Medicine, Istanbul, Turkiye
3Department of Medical Biology, Eastern Mediterranean University School of Medicine, Famagusta, Turkish Republic of Northern Cyprus
Hepatology Forum 2024; 5(2): 93-96 DOI: 10.14744/hf.2023.2023.0018 PMCID: PMC10936119
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Coronavirus disease-2019 (COVID-19) is a novel multisystemic viral disease caused pandemic. The disease impact involves liver and associated systems. Undoubtedly, host genetic background influences the predisposition and pre-diction of infection. Variants among human populations might increase sus-ceptibility or protect against severe outcomes. In this manner, rs738409 vari-ant of patatin-like phospholipase domain-containing protein 3 gene appears to be protective in some populations in spite of its aggravating effect on non-al-coholic fatty liver diseases (NAFLDs) and steatohepatitis. DRB1*15:01 allele of human leukocyte antigen is associated with protective effect in European and Japanese populations. DRB1*03:01 contrarily increases the susceptibility of severe COVID-19 infection in European populations. rs1260326 in glu-cokinase regulatory protein gene, rs112875651 in tribbles homolog 1 gene, rs429358 in apolipoprotein 1, and rs58542926 in transmembrane 6 superfam-ily 2 alleles are found related with NAFLD and obesity; thus, hypercoagu-lability and severe COVID-19 outcomes. In chronic or acute liver diseases, comorbid syndromes are the key factors to explain increased severity. There might not be a direct association between the variant and severe COVID-19 infection. As it is concluded, there are genes and variants known and unknown yet to be studied to reveal the association with disease severity.