Fingolimod induced fulminant liver failure requiring liver transplantation: A case report
Ali Riza Caliskan1 , Muhsin Murat Muhip Harputluoglu2 , Emine Samdanci3 , Salih Cirik4 , Sezai Yilmaz5
1Department of Gastroenterology, Adiyaman Training and Research Hospital, Adiyaman, Turkiye
2Department of Gastroenterology, Inonu University School of Medicine, Malatya, Turkiye
3Department of Pathology, Inonu University School of Medicine, Malatya, Turkiye
4Department of Internal Medicine, Malatya Training and Research Hospital, Malatya, Turkiye
5Department of General Surgery, Liver Transplantation Institute, Inonu University School of Medicine, Malatya, Turkiye
2Department of Gastroenterology, Inonu University School of Medicine, Malatya, Turkiye
3Department of Pathology, Inonu University School of Medicine, Malatya, Turkiye
4Department of Internal Medicine, Malatya Training and Research Hospital, Malatya, Turkiye
5Department of General Surgery, Liver Transplantation Institute, Inonu University School of Medicine, Malatya, Turkiye
Abstract
Fingolimod has been used for about ten years to treat multiple recurrent sclerosis. It has been reported that Fingolimod causes an elevation in liver enzymes. In this case report, the clinical and laboratory parameters im-proved after discontinuation of the drug. However, there is no publication in the literature regarding acute liver failure and liver transplantation fol-lowing Fingolimod treatment. In this article, we presented a 33 – year – old female patient who developed acute liver failure and underwent liver transplantation after Fingolimod treatment for recurrent multiple sclerosis.
Keywords: Acute liver failure; drug-induced liver injury; fingolimod; liver transplantation; multiple sclerosis.
