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Can first-trimester aspartate aminotransferase/platelet ratio index score predict intrahepatic cholestasis of pregnancy?
1Department of Obstetrics and Gynecology, Sakarya University School of Medicine, Sakarya, Turkiye
2Department of Obstetrics and Gynecology, Bezmialem University School of Medicine, Istanbul, Turkiye
3Department of Obstetrics and Gynecology, Sakarya Training and Research Hospital, Sakarya, Turkiye
4Department of Obstetrics and Gynecology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkiye
5Department of Obstetrics and Gynecology, Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Istanbul, Turkiye
Hepatology Forum 2023; 1(4): 30-34 DOI: 10.14744/hf.2022.2022.0031
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Abstract

Background and Aim: The study aimed to investigate the effectiveness of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and platelet values in predicting intrahepatic cholestasis of pregnancy (ICP) in the first trimester, together with the aspartate aminotransferase/platelet ratio index (APRI) score.
Material and Methods: This study consisted of a patient group diagnosed with ICP (n=49) and a control group (n=62). Laboratory tests of both groups were analyzed retrospectively.
Results: The first-trimester APRI score and AST and ALT values were found to be statistically significantly higher than those of the control group. The platelet value was found to be statistically significantly lower in the study group, even though it was within the normal reference range.
Conclusion: The first-trimester APRI score was found to be effective in predicting ICP. In addition, the first-trimester AST, ALT, and platelet values were found to be effective in predicting ICP diagnosed in the third trimester even though if not as much as the APRI score.