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Development of hepatocellular carcinoma in patients with chronic hepatitis C who had sustained viral response following direct-acting antiviral therapy
1Department of Gastroenterology, University of Health Sciences, Diyabakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkiye
2Deparment of Internal Medicine, Dicle University School of Medicine, Diyarbakir, Turkiye
3Department of Gastroenterology, Ministry of Health Manisa City Hospital, Manisa, Turkiye
4Department of Gastroenterology, Adiyaman Training Hospital, Adiyaman; Turkiye
5Department of Biochemistry, Recep Tayyip Erdogan University Schoool of Medicine, Rize, Turkiye
6Deparment of Gastroenterology, Dicle University School of Medicine, Diyarbakir, Turkiye
Hepatology Forum 2022; 3(3): 82-87 DOI: 10.14744/hf.2022.2022.0016 PMCID: PMC9510740
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Background and Aim: Several studies have suggested that treatment with direct-acting antivirals (DAAs) in patients with chronic hepatitis C virus (HCV) may be associated with an increased risk of developing hepatocellular carcinoma (HCC). We investigated the incidence and risk factors of HCC in HCV patients who achieved a sustained virologic response (SVR) following DAA therapies.
Material and Methods: The medical data of patients who were diagnosed with HCV and received DAA therapy in two tertiary centers in Turkey were retrospectively collected.
Results: Among them, 75 patients (52.4%) were noncirrhotic and 68 patients (47.6%) were cirrhotic. The overall SVR rate was 97.2% (139/143). It was 100% in noncirrhotic and 94.1% in cirrhotic patients. HCC was developed in 5 (7.4%) patients, all of whom had baseline cirrhosis. The annual rate of HCC occurrence was 2.94%, and the 5-year cumulative incidence of HCC was 7.3%. The mean Child-Pugh score (CPS) and Model for End-Stage Liver Disease (MELD) score significantly decreased after DAA treatment (CPS 7.0 vs 5.9, p=0.001; MELD 10.8 vs 9.5, p=0.003).
Conclusion: There was no significant increase in the rate of HCC in cirrhotic HCV patients treated with DAAs. This treatment led to a remarkably high SVR rate and lowered CPS and MELD scores in cirrhotic HCV patients.