Acute liver injury and IgG4-related autoimmune pancreatitis following mRNA-based COVID-19 vaccination

H Patel, Ankoor; Amin, Rajan; Lalos, Alexander T.

doi:10.14744/hf.2022.2022.0019

Ankoor H Patel¹ ,

Rajan Amin² ,

Alexander T. Lalos²

¹Internal Medicine, Robert Wood Johnson Medical School, Rutgers Biomedical and Health Sciences (RBHS), Rutgers University, New Brunswick, NJ, USA
²Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA

Hepatology Forum 2022; 3(3): 97-99 DOI: 10.14744/hf.2022.2022.0019 PMCID: PMC9510734

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Abstract

IgG4-related disease (IgG4-RD) is a fibro-inflammatory disease that can affect multiple organs. Autoimmune pancreatitis type 1 is a manifestation of IgG4-related disease and can often mimic tumor-like masses. Autoimmune phenomena following COVID-19 mRNA vaccination are being increasingly reported. Currently, there are no cases in which IgG4-RD involving the hepatobiliary system has been reported following the COVID-19 vaccination. We present the first case of IgG4-RD and AIP type 1 to be associated with the mRNA-based COVID-19 vaccination.

Keywords: Autoimmune pancreatitis; COVID-19; mRNA vaccine; IgG4.